Aortoiliac occlusive disease is a peripheral arterial disease that occurs when one or more of the primary arteries in the pelvis become narrowed or blocked completely. The condition is caused by atherosclerosis, or hardening of the arteries.

Plaque buildup in the arteries is the primary cause of aortoiliac occlusive disease, and the risk factors for this condition include smoking and high blood pressure/high cholesterol.

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There is a range of symptoms associated with aortoiliac disease that occur at different points in its progression. Some of the main symptoms include cramping/pain or fatigue during exercise (disappearing during rest) in the thigh, leg, and buttock areas.

More severe symptoms can include continuous pain or coldness/numbness in the legs, sores on the lower leg or heels and toes, atrophy/shrinking of muscles, and even gangrene in the most serious cases.